Lead Compound Identification Chemistry Assignment Help

Lead Compound Identification

For the synthesis and selection of biologically relevant compounds a large number of compounds are tested for their ability to effect the action of target proteins.

Compounds are mainly identified using random screening or through design approaches. For a compound to be identified as potential drug it should fulfill the following criteria:

a) Pharmacodynamics properties- efficacy, potency, selectivity.

b) Physiochemical properties- water solubility, chemical stability.

c) Pharmacokinetic properties- metabolic stability and toxicological aspects.

d) Chemical optimization potential- ease of chemical synthesis and derivatization.

e) Patentability.

The drug designing and discovery process include the following major steps:

1. Drug Target Identification
2. Target Validation
3. Lead Compound Identification
4. Lead Optimization
5. Preclinical And Clinical development
6. Administration of Drugs
7. Absorption Of Drugs
8. Drug Assays
9. Preservation Of Pharma Product

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