It concerns with mapping out the 3-D structure and nature of protein complexes present specifically in a particular cell/organelle. Its aim is to build a body of structural information that will help predict the probable structure and potential function for almost any protein from knowledge of its coding sequence. It also helps in assembling information about protein-protein interactions and about architecture of cells to explain how the expression of certain proteins contributes in cell’s unique characteristics.
It refers to the use of proteomics techniques to analyze the characteristics of molecular protein-networks involved in a living cell. Its recent achievement is the identification and analysis of molecular protein-networks involved in the nuclear pore complex (NPC) in yeast.
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