NURS4301 Health Research Methods : Improve Human Health

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Scenario 1: Settings and facilities around the environment we live in (schools, workplaces or homes) can affect uptake of health screening services and/or healthy behaviour, and our health. Propose a study to investigate the relationship between the exposure factor (setting or facility of your choice) and outcome factor(s) (such as uptake of health screening services and/or healthy behaviour, specific physical or mental or sexual health status of your choice) in a target population of your interest.

Answer:

Literature Review

Synopsis

Title: A research study to determine the antimicrobial products that are produced by the probiotics used in bio preservation, which help in the probiotic antimicrobial activity that suppresses the diseases by pathogens in humans and helps, improve human health.

Background: Many research studies have been conducted on the scope of the antimicrobial activity by the probiotics (Neethu et al, 2014) and on their mechanism of actions in microbial interference therapy (Sarita, 2016). The antimicrobial substances produced by these microorganisms have been determined to include “organic acids, hydrogen peroxide and bacteriocins” (Dunne et al, 1999) with their biological antimicrobial mechanism of action determined to involve the competition for nutrients with the pathogens that inhibit the growth of these organisms (Reid and Burton, 2002). The knowledge of the kind and nature of the bacteriocins (biologically active proteins) produced by these microorganisms is wanting and the aspect that I intent to decipher through this research.

1. Probiotics are beneficial bio preservative.
2. Probiotics have antimicrobial activity.
3. Probiotics produce bacteriocins among many other antimicrobial substances.
4. Probiotics’ bacteriocins are of many different types.

Statistical Analyses:

1. Descriptive Statics:This will make use of tables to compare the results from the two species of animals used to obtain the cultures of the microbes and to compare the results of the strains derived from these cultures and how they tested for the various bacteriocins tests.
2. Inferential Statistics:This will involve the drawing of conclusions based on the data obtained on each strain of the probiotics examined.

Ethics Application: This proposal needs to be submitted to the Australian National University Human Research Ethics Committee.

Limitations of the Study: The biases that might occur during this study include:

1. Possible contamination of the samples during the collection and transportation process
2. Possible inappropriate isolation of the strains in the laboratory
3. Possible occurrence of inconclusive test results

Justification of proposed synopsis

My chosen descriptive statistical analysis is the use of comparison tables for the cultures obtained from the two different animal species and for the different strains of the microbes obtained from the cultures. The inference statistical analysis will involve simple conclusions of the data describing a single strain of the lactobacilli. I picked on these statistical analyses because they are easy to follow and understand.

My Choice of Human Research Ethics Committee(s) is the Australian National University Human Research Ethics Committee as the research will be conducted with affiliation to the University and hence will involve student participation.

References:

Mourad, K. and Mereim, K. H. (2008). Gracsas y aceites. 59, 3, 218-24

Neethu, K., Christy, G., Charles, L. P., and Bhaskara, R. K. V. (2014).Bio preservation of Meat by Probiotics Bacteria from Dairy Products. Der Pharmacia Lettre, 2014, 6(6): 226-271