Forums Assignment Help What was the contribution of Margaret Dayhoff?

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  • #440
    Aakanksha
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    What was the contribution of Margaret Dayhoff in the field of molecular evolution?

    #9001
    nammy
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    Margaret Dayhoff observed that protein sequences undergo variation during evolution according to certain patterns. She noted that:

    – Amino acids were not replaced at random but were altered with specific preferences. For example, amino acids of similar physico-chemical characteristics were preferred, one over another.

    – Some amino acids such as tryptophan, was generally not replaced by any other.

    – Based on several homologous sequences, a point accepted mutation (PAM) matrix could be developed. This laid the first foundation for subsequent work on sequence comparisons using quantitative approaches.

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